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c/tirzepatide·submitted 9 months ago by u/line_petrov

does Zepbound actually matter or is it forum lore at this point

Titrationbranch of 10 comments

Genuinely asking, not being difficult. Everyone in c/semaglutide repeats that dual agonist is important. I believe it, but I have never seen anyone show why, and when I search I get 4 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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10 comments, started 9 months ago
u/ewan_marchand237 points·9 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/curious_panel_only168 points·9 months ago

the constipation from tirz is different, not necessarily worse

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u/adnan_nascimento83 points·9 months ago

the reflux from tirz is different, not necessarily worse

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u/yusuf_ramos109 points·9 months ago

week 70 on Mounjaro and the appetite profile is genuinely different from sema

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u/amara_halonen67 points·9 months ago

dual agonism is SURPASS, do not generalise from semaglutide

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u/ignacio_vanhecke18 points·9 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/teodor_szabo39 points·9 months ago·edited

do not crack the pen, we have been over this

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u/adnan_nascimento-8 points·9 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/emil_barros21 points·9 months ago

the sulphur burps from tirz is different, not necessarily worse

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u/mikkel_ogunleye31 points·9 months ago

do not crack the pen, we have been over this

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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