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c/tirzepatide·posted 9 months ago by u/line_petrov

does Zepbound actually matter or is it forum lore at this point

Titration Long Haul ×8 Sourced ×1 Well Actually ×3

Genuinely asking, not being difficult.

Everyone in c/semaglutide repeats that dual agonist is important. I believe it, but I have never seen anyone show why, and when I search I get 4 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

4,970 up / 414 down92% upvoted50 commentsid p8wp8i14 Oct 2025

50 comments

27 in this archive, depth 6

best — the order this archive was captured in

u/ignacio_vanhecke976 points·9 months ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/line_petrovOP384 points·9 months ago

the fatigue from tirz is different, not necessarily worse

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u/noor_hovland816 points·9 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/two_mil_or_one270 points·9 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

Yes, exactly this, and it is the bit that took me 50 weeks to accept.

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u/mikkel_ogunleye980 points·9 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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[removed]299 points·9 months ago

[removed by moderator]

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u/teodor_szabo467 points·9 months ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/incretin_ivyMOD191 points·9 months ago

Tracking number removed. It identifies both ends of a shipment.

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u/certified_referenceQC359 points·9 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/ewan_marchand237 points·9 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/curious_panel_only168 points·9 months ago

the constipation from tirz is different, not necessarily worse

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u/adnan_nascimento83 points·9 months ago

the reflux from tirz is different, not necessarily worse

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u/yusuf_ramos109 points·9 months ago

week 70 on Mounjaro and the appetite profile is genuinely different from sema

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u/amara_halonen67 points·9 months ago

dual agonism is SURPASS, do not generalise from semaglutide

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u/ignacio_vanhecke18 points·9 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/teodor_szabo39 points·9 months ago·edited

do not crack the pen, we have been over this

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u/adnan_nascimento-8 points·9 months ago

The confident tone is doing a lot of work that the evidence is not.

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u/emil_barros21 points·9 months ago

the sulphur burps from tirz is different, not necessarily worse

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u/mikkel_ogunleye31 points·9 months ago

do not crack the pen, we have been over this

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u/halima_boateng200 points·9 months ago·edited

SURMOUNT data is messier than STEP data but the weight loss is there

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u/kaia_cabrera65 points·9 months ago·edited

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/line_petrovOP74 points·9 months ago

the 15mg is the top of the pen, not the required dose

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u/kaia_wojcik88 points·9 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/taper_off_tabitha31 points·9 months ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

Disagree on that part. 98.1% and 98.9% on the same vial is normal.

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u/aksel_kjaer109 points·9 months ago

Respectfully this is a sample of one presented as a finding.

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u/britt_okwuosa76 points·9 months ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/sten_bhattacharya34 points·9 months ago

Is that on Mounjaro pens or research tirzepatide?

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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