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c/tirzepatide·submitted 26 days ago by u/dario_vermeulen

my resting HR went from 58 to 66 on titration and settled back

Questionbranch of 9 comments

tirzepatide. That is the whole post, but I will justify it. Everything else people worry about in c/intlshipping is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort tirzepatide out first, and almost nobody does. I say this having got it wrong for 12…

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9 comments, started 24 days ago
u/curious_panel_only23 points·24 days ago

This matches the trial data. SURMOUNT-1 was 97.6% body weight at 16 weeks.

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u/bastian_eriksen7 points·24 days ago

stalled on sema, tried tirz, and the curves were actually different shapes

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u/dario_vermeulenOP4 points·24 days ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/ahmed_fonseca3 points·24 days ago

dual agonism is SURPASS, do not generalise from semaglutide

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u/kofi_balogun3 points·24 days ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/elin_ferrari4 points·24 days ago

Is that on Mounjaro pens or research tirzepatide?

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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