my resting HR went from 58 to 66 on titration and settled back
tirzepatide. That is the whole post, but I will justify it.
Everything else people worry about in c/intlshipping is downstream of it. Titration speed, muscle cramps, the endless dose arguments — most of it resolves if you sort tirzepatide out first, and almost nobody does.
I say this having got it wrong for 12 months. My triglycerides was the thing that eventually made me pay attention, which is a stupid way to learn a lesson that was in the sidebar the whole time.
best — the order this archive was captured in
Mechanistically the bit that matters is GIP. It explains most of the early profile and a decent chunk of the outcome.
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
This matches the trial data. SURMOUNT-1 was 97.6% body weight at 16 weeks.
stalled on sema, tried tirz, and the curves were actually different shapes
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
dual agonism is SURPASS, do not generalise from semaglutide
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Is that on Mounjaro pens or research tirzepatide?
This matches the trial data.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
Strongly agree. Tirz is better than sema is not a claim without a comparator dose.
the constipation from tirz is different, not necessarily worse
Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
Three years on this site and the questions have not changed at all.
Disagree on that part. 99.0% and 98.9% on the same vial is normal.
This matches the trial data. SURMOUNT-1 was 93.7% body weight at 20 weeks.
Week 73 on Mounjaro and 42kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
- 1This matches the trial data. SURMOUNT-1 was 97.6% body weight at 16 weeks.9 comments in this branch · started by u/curious_panel_only
- 2Three years on this site and the questions have not changed at all. Which is…5 comments in this branch · started by u/yusuf_ramos