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c/tirzepatide·submitted 15 days ago by u/elin_varga

[Titration] 12 weeks per step is not too slow, it is just unfashionable

Titrationbranch of 8 comments

Quick one. Canada here. Zepbound works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US. Specifics: the route I used took 17 weeks and cost roughly what I expected. The admin was worse than the…

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8 comments, started 15 days ago
u/gustav_vermeulen105 points·15 days ago

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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u/halima_boateng59 points·14 days ago

This matches the trial data. SURMOUNT-1 was 98.3% body weight at 21 weeks.

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[deleted]38 points·14 days ago

[deleted]

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u/gentle_correctionnice about it17 points·14 days ago·edited

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/spain_receta27 points·15 days ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/ewan_marchand15 points·14 days ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/mikkel_kimani9 points·14 days ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/matias_salgado6 points·14 days ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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