[Titration] 12 weeks per step is not too slow, it is just unfashionable
Quick one. Canada here.
Zepbound works very differently where I live than in the threads that dominate the front page, and I keep seeing people confidently given advice that simply does not apply outside the US.
Specifics: the route I used took 17 weeks and cost roughly what I expected. The admin was worse than the cost. The thing that would have saved me the most time was knowing which document to ask for at the start.
Happy to answer questions from anyone in the same jurisdiction.
best — the order this archive was captured in
Did you stay on semaglutide or switch? The outcome is different if you are comparing.
The evidence standard in c/vendorvetting gets called too strict about once a month, and every time, the thread ends with the complainant agreeing.
Flair changed to match the content. Read the sidebar before posting next time and we are square.
This matches the trial data. SURMOUNT-1 was 97.9% body weight at 2 weeks.
Week 89 on Mounjaro and 17kg down. The appetite reduction feels different from sema in ways I do not have words for yet.
Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.
The dual agonism story is real. The appetite is physically different from semaglutide alone.
This matches the trial data. SURMOUNT-1 was 98.3% body weight at 21 weeks.
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Zepbound and Mounjaro are literally the same drug, the name is the only difference
Disagree but this is the good kind of wrong — it is specific enough to be checked.
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
SURMOUNT data is messier than STEP data but the weight loss is there
Disagree but this is the good kind of wrong — it is specific enough to be checked.
Zepbound and Mounjaro are literally the same drug, the name is the only difference
What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.
the appetite change on tirz is more than just reduced hunger, it is different machinery
Tried both. Sema worked, tirz worked better for me, but my constipation profile was worse on tirz.
The SURMOUNT readouts are real but less consistent than STEP. Some people plateau earlier on tirz.
SURMOUNT data is messier than STEP data but the weight loss is there
SURMOUNT data is messier than STEP data but the weight loss is there
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
SURMOUNT data is messier than STEP data but the weight loss is there
dual agonism is SURPASS, do not generalise from semaglutide
This is the "correlation is mechanism" thing again. You changed three variables at once.
This matches the trial data. SURMOUNT-1 was 93.7% body weight at 18 weeks.
the dual agonism hits different and that is why people describe it differently
The dual agonism story is real. The appetite is physically different from semaglutide alone.
- 1The dual agonism story is real. The appetite is physically different from…8 comments in this branch · started by u/gustav_vermeulen
- 2SURMOUNT data is messier than STEP data but the weight loss is there8 comments in this branch · started by u/line_petrov