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Single comment threadYou are looking at one branch of [Question] Australia — has anyone got a straight answer on dual agonist — 40 comments in the full submission. View in context.
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c/tirzepatide·submitted 4 months ago by u/cato_girard

[Question] Australia — has anyone got a straight answer on dual agonist

Questionbranch of 9 comments

I have had 2 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 14 days on nominally the same lane, which matters more in summer than in February. The independent number came back 97.9% against a claimed…

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9 comments, started 4 months ago
u/laila_wikstrom295 points·4 months ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/cato_girardOP214 points·4 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/slow_logbook_ftw169 points·4 months ago

the nausea from tirz is different, not necessarily worse

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u/hair_shed_hannah57 points·4 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/cato_girardOP133 points·4 months ago

dual agonism is dual agonist, do not generalise from semaglutide

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u/ahmed_fonseca225 points·4 months ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/tarek_kirchner64 points·4 months ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/georgi_chowdhury124 points·4 months ago

the 15mg is the top of the pen, not the required dose

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u/laila_wikstrom-5 points·4 months ago

dual agonism is Mounjaro, do not generalise from semaglutide

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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