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c/tirzepatide·posted 2 months ago by u/cato_girard

what would you tell week-1 you about Mounjaro

Side Effects Well Actually ×2 Sourced ×3

Right, the Mounjaro question again, but with numbers this time.

I have 15 data points over 18 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign.

The thing I would flag for anyone new: the effect I am describing showed up at week 85, not week 39. People give up long before the interesting part.

Interested in whether this matches other people's logs or whether I am an outlier.

1,484 up / 217 down87% upvoted39 commentsid 1s31e811 May 2026

39 comments

21 in this archive, depth 4

best — the order this archive was captured in

u/neha_falk171 points·2 months ago

Is that on Mounjaro pens or research tirzepatide?

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u/dario_stanescu42 points·2 months ago

dual agonism is SURPASS, do not generalise from semaglutide

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u/samir_falk135 points·2 months ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/line_petrov74 points·2 months ago

My triglycerides moved faster on tirz than on sema at the same timepoint, which matches what people report.

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u/search_before_post112 points·2 months ago

I am going to push back on this slightly.

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u/hair_shed_hannah107 points·2 months ago

the early fullness from tirz is different, not necessarily worse

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u/ghrp_history31 points·2 months ago

Small correction: the trial was 13 weeks, not 38. Does not change your point but people will quote it.

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u/dexa_twice_yearlybody comp13 points·2 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/mod_cold_roommod · c/coldchain21 points·2 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/ferritin_low56 points·2 months ago

Vial-splitting is on-topic here. Do not ask about pen-cracking, that goes in c/reconstitution.

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u/cato_girardOP23 points·2 months ago

the muscle cramps from tirz is different, not necessarily worse

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u/zaid_balogun13 points·2 months ago

week 26 on Mounjaro and the appetite profile is genuinely different from sema

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u/samir_falk3 points·2 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/zeynep_zielinski11 points·2 months ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/cato_girardOP36 points·2 months ago

Not convinced. The evidence does not support that reading.

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[deleted]15 points·2 months ago

[deleted]

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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