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c/tirzepatide·posted 2 months ago by u/kian_ekstrom

[Meta] the Zepbound rule is doing its job and people should stop complaining

Titration Long Haul ×3 Well Actually ×1

Posting this because I searched for it and got nothing useful.

Setup: 10mg, week 76, injection-site soreness present but not ruining anything. I changed exactly one variable — SURPASS — and tracked it for 7 weeks.

Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am putting it here rather than presenting it as a finding. If two or three other people have done the same thing we might actually learn something.

Not medical advice, obviously. This is one person with a spreadsheet.

2,442 up / 136 down95% upvoted32 commentsid 1rt1sj6 May 2026

32 comments

13 in this archive, depth 5

best — the order this archive was captured in

u/ghrp_history334 points·2 months ago

What was the trial arm you are quoting from? SURMOUNT-1, -2, -3 are all different.

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u/kofi_balogun277 points·2 months ago

the GIP side does different things than the GLP-1 side, that is the point

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[removed]110 points·2 months ago

[removed by moderator]

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u/two_mil_or_one38 points·2 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/laila_yilmaz-26 points·2 months ago

the GIP side does different things than the GLP-1 side, that is the point

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u/dexa_twice_yearlyMOD137 points·2 months ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/ahmed_fonseca113 points·2 months ago·edited

stalled on sema, tried tirz, and the curves were actually different shapes

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u/tarek_kirchner80 points·2 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/noor_hovland37 points·2 months ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/amara_halonen34 points·2 months ago

week 21 on Mounjaro and the appetite profile is genuinely different from sema

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u/nordic_pricing28 points·2 months ago·edited

the GIP side does different things than the GLP-1 side, that is the point

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u/blunt_coldbox2932 points·2 months ago

Slight fix: the number was 97.6, not 98.0. Decimal point, but a fairly consequential one.

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u/yusuf_ramos133 points·2 months ago

This matches the trial data. SURMOUNT-1 was 98.6% body weight at 23 weeks.

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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