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c/tirzepatide·submitted 3 months ago by u/elin_varga

[Meta] proposal — a flair for tirzepatide posts

Resultsbranch of 9 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking SURMOUNT against ApoB for 3 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one assay,…

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9 comments, started 3 months ago
u/discount_math_dm202 points·3 months ago

Hard agree. The food noise disappears differently on the two compounds.

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u/copay_card_cc55 points·3 months ago

That is net peptide content, not purity. Different number, different meaning.

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u/slow_logbook_ftw44 points·3 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/titration_marshalmod · c/semaglutide-4 points·3 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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u/dario_stanescu44 points·3 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/noor_hovland35 points·3 months ago·edited

SURMOUNT data is messier than STEP data but the weight loss is there

Yes, exactly this, and it is the bit that took me 71 weeks to accept.

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[deleted]15 points·3 months ago

[deleted]

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u/amara_halonen18 points·3 months ago

week 28 on Mounjaro and the appetite profile is genuinely different from sema

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u/aksel_kjaer10 points·3 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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