GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
3.1k
c/tirzepatide·posted 3 months ago by u/elin_varga

[Meta] proposal — a flair for tirzepatide posts

Results Clean Column ×8 Cold Box ×1 Long Haul ×1

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking SURMOUNT against ApoB for 3 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

3,854 up / 735 down84% upvoted18 commentsid 1p15rm6 Apr 2026

18 comments

15 in this archive, depth 5

best — the order this archive was captured in

u/emil_barros453 points·3 months ago·edited

This matches the trial data. SURMOUNT-1 was 97.9% body weight at 18 weeks.

replysharereportpermalink
u/mikkel_ogunleye664 points·3 months ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

replysharereportpermalink
u/gustav_vermeulen238 points·3 months ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

replysharereportpermalink
load more comments (2) →
u/discount_math_dm202 points·3 months ago

Hard agree. The food noise disappears differently on the two compounds.

replysharereportpermalink
u/copay_card_cc55 points·3 months ago

That is net peptide content, not purity. Different number, different meaning.

replysharereportpermalink
u/slow_logbook_ftw44 points·3 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

replysharereportpermalink
u/titration_marshalmod · c/semaglutide-4 points·3 months ago

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

replysharereportpermalink
u/dario_stanescu44 points·3 months ago

SURMOUNT data is messier than STEP data but the weight loss is there

replysharereportpermalink
u/noor_hovland35 points·3 months ago·edited

SURMOUNT data is messier than STEP data but the weight loss is there

Yes, exactly this, and it is the bit that took me 71 weeks to accept.

replysharereportpermalink
[deleted]15 points·3 months ago

[deleted]

replysharereportpermalink
u/amara_halonen18 points·3 months ago

week 28 on Mounjaro and the appetite profile is genuinely different from sema

replysharereportpermalink
u/aksel_kjaer10 points·3 months ago

stalled on sema, tried tirz, and the curves were actually different shapes

replysharereportpermalink
u/line_petrov210 points·3 months ago·edited

This matches the trial data. SURMOUNT-1 was 96.2% body weight at 22 weeks.

replysharereportpermalink
Permalinked branches
Deep branches get their own page so a single reply chain can be linked and read on its own.
About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

187kmembers
130submissions
Aug 2023created
submissions / month, last year
Sponsored

PeptideMeter Analytics

Independent testing plus vendor-level trend data. Community-funded, unaffiliated.

peptidemeter.com
More in c/tirzepatide
c/tirzepatide rules
  1. "Tirz is better than sema" needs a comparator dose or it is a vibe, not a claim.
  2. Vial-splitting and self-compounding discussion stays in c/reconstitution.
  3. No pen-cracking tutorials. Discussing that people do it is fine; instructions are not.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/titration_marshalu/incretin_ivyu/quiet_moderatoru/dexa_twice_yearly
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →