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c/tirzepatide·submitted 2 years ago by u/elin_varga

[Discussion] dual agonist is doing more work than we give it credit for

Discussionbranch of 9 comments

Week 87 update. 43kg down from the start, reflux basically gone since about week 44. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux. The part that surprised me is how much of this is admin. Ordering,…

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9 comments, started 2 years ago
u/yusuf_ramos119 points·2 years ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/alcohol_aversion175 points·2 years ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/elin_vargaOP128 points·2 years ago

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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u/kofi_balogun43 points·2 years ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/priya_guerrero0 points·2 years ago

This matches the trial data. SURMOUNT-1 was 98.1% body weight at 15 weeks.

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u/yusuf_ramos1 point·2 years ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/emil_okwuosa91 points·2 years ago

This matches the trial data. SURMOUNT-1 was 98.3% body weight at 4 weeks.

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u/b12_baseline26 points·2 years ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/swirl_dont_shakereconstitution55 points·2 years ago·edited

do not crack the pen, we have been over this

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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