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c/tirzepatide·posted 2 years ago by u/elin_varga

[Discussion] dual agonist is doing more work than we give it credit for

Discussion Long Haul ×7 Clean Column ×2 Well Actually ×2

Week 87 update. 43kg down from the start, reflux basically gone since about week 44.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

5,722 up / 546 down91% upvoted35 commentsid 15o8jz4 Apr 2024

35 comments

19 in this archive, depth 5

best — the order this archive was captured in

u/incretin_ivyMOD291 points·2 years ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/elin_vargaOP186 points·2 years ago·edited

Small correction: the trial was 5 weeks, not 36. Does not change your point but people will quote it.

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u/gustav_vermeulen216 points·2 years ago

I am going to push back on this slightly.

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u/elin_vargaOP124 points·2 years ago

Week 21 on Mounjaro and 27kg down. The appetite reduction feels different from sema in ways I do not have words for yet.

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u/curious_panel_only193 points·2 years ago·edited

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/thyroid_tangent146 points·2 years ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

Disagree on that part. 96.8% and 96.2% on the same vial is normal.

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[removed]64 points·2 years ago

[removed by moderator]

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u/discount_math_dm48 points·2 years ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/tarek_lokken26 points·2 years ago

Disagree but this is the good kind of wrong — it is specific enough to be checked.

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u/tidy_vialdrawer_pls33 points·2 years ago·edited

stalled on sema, tried tirz, and the curves were actually different shapes

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u/yusuf_ramos119 points·2 years ago

I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.

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u/alcohol_aversion175 points·2 years ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/elin_vargaOP128 points·2 years ago

The dual agonism story is real. The appetite is physically different from semaglutide alone.

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u/kofi_balogun43 points·2 years ago

SURMOUNT data is messier than STEP data but the weight loss is there

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u/priya_guerrero0 points·2 years ago

This matches the trial data. SURMOUNT-1 was 98.1% body weight at 15 weeks.

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u/yusuf_ramos1 point·2 years ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/emil_okwuosa91 points·2 years ago

This matches the trial data. SURMOUNT-1 was 98.3% body weight at 4 weeks.

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u/b12_baseline26 points·2 years ago

Yeah, dual agonism does produce a different appetite profile than GLP-1 alone.

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u/swirl_dont_shakereconstitution55 points·2 years ago·edited

do not crack the pen, we have been over this

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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