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c/tirzepatide·submitted 2 years ago by u/tarek_kirchner

small win: GIP stopped being a problem at week 81

Questionbranch of 10 comments

Week 24 update. 25kg down from the start, reflux basically gone since about week 76. Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with reflux. The part that surprised me is how much of this is admin. Ordering,…

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10 comments, started 2 years ago
u/elin_ferrari676 points·2 years ago
that is the funniest sentence i have read on this site
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u/customs_seizure_sid-17 points·2 years ago

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/mikkel_ogunleye1 point·2 years ago

Cosigning. The GIP contribution is real and the side effects are not simply scaled versions.

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u/nabila_ogunleye409 points·2 years ago

that is the funniest sentence i have read on this site

Adding to this: Mounjaro is doing more work than the comment implies.

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u/dario_stanescu339 points·2 years ago·edited

Zepbound and Mounjaro are literally the same drug, the name is the only difference

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u/ahmed_fonseca104 points·2 years ago·edited

Strongly agree. Tirz is better than sema is not a claim without a comparator dose.

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u/b12_baseline71 points·2 years ago

Strongly agree.

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/ahmed_fonseca18 points·2 years ago

do not crack the pen, we have been over this

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u/tarek_kirchnerOP185 points·2 years ago

Zepbound and Mounjaro are literally the same drug, the name is the only difference

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/tarek_kirchnerOP115 points·2 years ago

dual agonism is GIP, do not generalise from semaglutide

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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