24 months in and SURPASS is still the thing I get wrong
Trying to settle this properly because the thread from last year went in circles.
The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 15 months without either producing anything.
What would actually settle it is 19 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
the GIP side does different things than the GLP-1 side, that is the point
the appetite change on tirz is more than just reduced hunger, it is different machinery
the dual agonism hits different and that is why people describe it differently
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing
Disagree on that part. 97.9% and 97.6% on the same vial is normal.
Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.
This matches the trial data. SURMOUNT-1 was 96.2% body weight at 11 weeks.
Hard agree. The food noise disappears differently on the two compounds.
SURMOUNT data is messier than STEP data but the weight loss is there
week 85 on Mounjaro and the appetite profile is genuinely different from sema
Tracking number removed. It identifies both ends of a shipment.
the early fullness from tirz is different, not necessarily worse
SURMOUNT data is messier than STEP data but the weight loss is there
SURMOUNT data is messier than STEP data but the weight loss is there
the appetite change on tirz is more than just reduced hunger, it is different machinery
the dual agonism hits different and that is why people describe it differently
Is that on Mounjaro pens or research tirzepatide?
Tracking number removed.
Yes, exactly this, and it is the bit that took me 95 weeks to accept.
The dual agonism story is real. The appetite is physically different from semaglutide alone.
the GIP side does different things than the GLP-1 side, that is the point
the appetite change on tirz is more than just reduced hunger, it is different machinery
- 1Tracking number removed. It identifies both ends of a shipment.8 comments in this branch · started by u/titration_marshal
- 2n=1 but same5 comments in this branch · started by u/thyroid_tangent