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c/tirzepatide·submitted 2 years ago by u/hugo_bergstrom

24 months in and SURPASS is still the thing I get wrong

Resultsbranch of 5 comments

Trying to settle this properly because the thread from last year went in circles. The claim: tirzepatide matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 15 months without either producing anything. What would actually settle it is 19 people measuring the…

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5 comments, started 2 years ago
u/thyroid_tangent-21 points·2 years ago
n=1 but same
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u/crosspost_bot_no1 point·2 years ago·edited

the GIP side does different things than the GLP-1 side, that is the point

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u/graph_it_gary1 point·2 years ago

the appetite change on tirz is more than just reduced hunger, it is different machinery

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u/piotr_nascimento1 point·2 years ago

the dual agonism hits different and that is why people describe it differently

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u/noor_hovland1 point·2 years ago·edited

nope, the equivalence to semaglutide is not known, comparing 15mg tirz to 2.4mg sema is guessing

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About c/tirzepatide

Tirzepatide-specific discussion: the dual-agonist pharmacology, the 2.5 → 15mg ladder, the appetite profile people describe as different from semaglutide, and the SURMOUNT/SURPASS trial programme. Comparisons with semaglutide are welcome as long as they are specific about dose equivalence being unknown.

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