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c/t2dglp1·submitted 1 year ago by u/emil_okwuosa

[Question] Australia — has anyone got a straight answer on metformin

Questionbranch of 7 comments

Genuinely asking, not being difficult. Everyone in c/dosinglogs repeats that glycaemic control is important. I believe it, but I have never seen anyone show why, and when I search I get 14 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true…

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7 comments, started 1 year ago
u/lucia_balogun57 points·1 year ago·edited
^ this
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u/nils_ferreira44 points·1 year ago

glycaemic control first, that is the original indication

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u/emil_okwuosaOP34 points·1 year ago

glycaemic control first, that is the original indication

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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u/rania_marchand-11 points·1 year ago

metformin combo is standard

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u/gradient_goblin23 points·1 year ago

CGM traces tell a story, numbers alone do not

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u/runa_grimaldi38 points·1 year ago

The confident tone is doing a lot of work that the evidence is not.

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u/tired_ledger_notes44 points·1 year ago

hypoglycaemia risk when stacked with A1c

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Type 2 diabetes as the original indication: A1c trajectories, CGM traces, hypoglycaemia risk when stacked with sulfonylureas or insulin, metformin combinations, and why the weight-loss conversation sometimes drowns out the glycaemic one.

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