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c/semaglutide·posted 1 year ago by u/greta_perrin

[Discussion] the Wegovy advice in here is 16 years out of date

Discussion Well Actually ×3 The Quiet One ×1 Receipts ×2

Genuinely asking, not being difficult.

Everyone in c/coldchain repeats that titration is important. I believe it, but I have never seen anyone show why, and when I search I get 3 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

11,968 up / 4,094 down75% upvoted52 commentsid 1cx7bt19 Oct 2024

52 comments

25 in this archive, depth 5

best — the order this archive was captured in

u/freya_baptista609 points·1 year ago

Strongly agree. If it is not working at 7.5mg after 25 weeks, going up is not automatically the answer.

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u/osman_ferrari160 points·1 year ago

Strongly agree.

Disagree on that part. 97.4% and 97.6% on the same vial is normal.

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u/units_not_mgMOD567 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/greta_perrinOP292 points·1 year ago

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.

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u/vikram_ferreira75 points·1 year ago

titration speed is plateau plus side effects, period

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u/freya_baptista357 points·1 year ago·edited

week 24 on the pen, 46kg down, this is the answer

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u/ahmed_okafor417 points·1 year ago

the quiet is real. the food noise just stops.

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u/rania_diallo-9 points·1 year ago

What colour is the pen? Wegovy and Ozempic use different formulations.

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u/noor_hovland227 points·1 year ago

the 2.4mg dose is not the target, it is just what the pen goes up to

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u/prior_auth_painappeals158 points·1 year ago

Slight fix: the number was 98.7, not 99.3. Decimal point, but a fairly consequential one.

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u/rania_diallo42 points·1 year ago

Not to be pedantic but plateau and food noise are being used interchangeably and they are not interchangeable in real life.

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u/anya_antonsen13 points·1 year ago

week 3 and i am still not at maintenance, do not rush the ladder

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u/units_not_mgsyringe math453 points·1 year ago

okay but what dose of sema are you on

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u/rohan_steiner251 points·1 year ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/coa_janitormod · c/coa215 points·1 year ago

Did anything else change in the same window? Sleep, protein, steps, anything?

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u/yara_boateng290 points·1 year ago

Right, and the corollary is that stopping escalation does not reset your tolerance, it just pauses the clock.

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u/aleksi_grimaldi103 points·1 year ago

Week 95 for me and the honest summary is: 43kg down, sulphur burps manageable, and the quiet happened around week 23.

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u/greta_perrinOP59 points·1 year ago

This matches my experience almost exactly on the Ozempic pens. The titration is the whole point.

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u/katrin_diallo76 points·1 year ago

week 84 and i am still not at maintenance, do not rush the ladder

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u/adaeze_brandt134 points·1 year ago·edited

the quiet is real. the food noise just stops.

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u/prior_auth_painappeals57 points·1 year ago

the quiet is real.

Adding to this: weekly dosing is doing more work than the comment implies.

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[removed]89 points·1 year ago

[removed by moderator]

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u/kavya_radich93 points·1 year ago
appreciate you saying you do not know
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u/ravi_bergstrom48 points·1 year ago

Yeah, 39 weeks on 0.5mg, same pattern, same timing.

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u/salma_vasquez13 points·1 year ago

the 2.4mg dose is not the target, it is just what the pen goes up to

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