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c/retatrutide·posted 2 months ago by u/nadia_trevino

[Meta] the retatrutide rule is doing its job and people should stop complaining

Discussion Cold Box ×6

Been lurking in c/progresspics for about 16 months and finally have something worth posting.

Short version: week 45, 7.5mg, and TRIUMPH is the bit I still cannot get a straight answer on. I have read the wiki, I have read the last 29 threads, and the answers split roughly down the middle.

What I actually want to know is whether the people saying it does not matter have measured it, or whether it is just repeated confidently. Happy to be told I am overthinking this — I probably am — but I would rather overthink it now than at week 39.

601 up / 218 down73% upvoted20 commentsid uifu2r12 May 2026

20 comments

17 in this archive, depth 4

best — the order this archive was captured in

u/injection_site_iris52 points·2 months ago·edited

What was the dosing schedule in that arm?

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u/mod_cold_roommod · c/coldchain22 points·2 months ago

the dosing is steep, the sulphur burps reports are real, and nobody knows the human safety yet

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u/incretin_ivypharmacology35 points·2 months ago·edited

Three years on this site and the questions have not changed at all. Which is depressing or reassuring depending on the day.

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u/trialwatch_theotrial nerd25 points·2 months ago

I am going to push back on this slightly.

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u/ledger_modmod · vetting8 points·2 months ago

the dosing is steep, the muscle cramps reports are real, and nobody knows the human safety yet

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u/burned_once_twice17 points·2 months ago
appreciate you saying you do not know
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u/reflux_report4 points·2 months ago

research use only, handling and analysis, not protocols

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u/sena_teixeira-32 points·2 months ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/elodie_grimaldi2 points·2 months ago

triple agonism is glucagon, do not generalise

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u/customs_seizure_sid0 points·2 months ago

TRIUMPH phase 2 showed 99.1% weight loss but the sulphur burps profile on the highest arm was rough. Phase 2 != phase 3.

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u/jarno_cabrera0 points·2 months ago

Are you quoting phase 2 or is there phase 3 data now?

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u/nausea_notesside effects1 point·2 months ago

research use only, handling and analysis, not protocols

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u/aa_analysis_andy1 point·2 months ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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[removed]1 point·2 months ago

[removed by moderator]

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u/rui_only_ro1 point·2 months ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/anya_moreau0 points·2 months ago

Not to be pedantic but triple agonist and retatrutide are being used interchangeably and they are not interchangeable in real life.

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u/nadia_trevino1 point·2 months ago

the dosing is steep, the constipation reports are real, and nobody knows the human safety yet

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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