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c/retatrutide·posted 1 year ago by u/andres_sorensen

genuine question about dose escalation that I am slightly embarrassed to ask

Trial Data Receipts ×3 Slow Clap ×1

Genuinely asking, not being difficult.

Everyone in c/glp1uk repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 22 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

1,512 up / 438 down78% upvoted37 commentsid kjjv215 Apr 2025

37 comments

10 in this archive, depth 4

best — the order this archive was captured in

u/honest_syringe33107 points·1 year ago

Not convinced. The evidence does not support that reading.

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u/sofia_wikstrom-36 points·1 year ago

heart rate and dose escalation need actual measurements, not impressions

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u/incretin_ivyMOD99 points·1 year ago

Retitled to remove editorialising. Put the evidence in the body.

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u/halima_mbeki44 points·1 year ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/mateusz_mensah38 points·1 year ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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[removed]27 points·1 year ago

[removed by moderator]

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u/rohan_cardoso18 points·1 year ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/ewan_marchand11 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/quiet_moderatormod6 points·1 year ago·edited

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/rui_only_ro23 points·1 year ago

That is net peptide content, not purity. Different number, different meaning.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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