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c/retatrutide·posted 2 years ago by u/placebo_arm_pam

[Lab] 19th independent test on QSC, and the trend is the interesting part

Lab Clean Column ×7 Cold Box ×3 Slow Clap ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking retatrutide against triglycerides for 37 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

22,481 up / 19,224 down54% upvoted40 commentsid fosbh013 Apr 2024

40 comments

19 in this archive, depth 3

best — the order this archive was captured in

u/hassan_nilsen690 points·2 years ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/placebo_arm_pamOP342 points·2 years ago

The glucagon component does different things than dual agonism. The the food-noise thing are not just amplified versions.

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u/honest_syringe33199 points·2 years ago

TRIUMPH phase 2 showed 99.3% weight loss but the reflux profile on the highest arm was rough. Phase 2 != phase 3.

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u/source_or_silence460 points·2 years ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/solene_ilunga303 points·2 years ago

Sceptical. If this were true we would see it reflected in the data and we do not.

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u/fabio_lehtinen68 points·2 years ago

triple agonism is phase 2, do not generalise

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u/careful_gradient32208 points·2 years ago

research use only, handling and analysis, not protocols

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u/placebo_arm_pamOP143 points·2 years ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/careful_gradient3236 points·2 years ago

research use only, handling and analysis, not protocols

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u/ewan_zielinski129 points·2 years ago

Mechanistically the bit that matters is dose escalation. It explains most of the early profile and a decent chunk of the outcome.

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u/anya_moreau96 points·2 years ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/placebo_arm_pamOP71 points·2 years ago

The heart rate signal in TRIUMPH is real and concerning. Higher doses had higher mean HR changes.

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u/andres_restrepo25 points·2 years ago

heart rate and dose escalation need actual measurements, not impressions

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u/fabio_lehtinen104 points·2 years ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/deleted_my_history67 points·2 years ago
IANAD and neither is anyone upvoting this
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u/burned_once_twice-30 points·2 years ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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[removed]1 point·2 years ago

[removed by moderator]

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u/trialwatch_theotrial nerd56 points·2 years ago·edited

This is correct. Triple agonism is genuinely different.

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u/careful_gradient3227 points·2 years ago

You have restated the marketing copy. What is the actual substance here.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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