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Single comment threadYou are looking at one branch of my A1c moved and I cannot work out whether glucagon is why — 36 comments in the full submission. View in context.
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c/retatrutide·submitted 25 days ago by u/arne_amankwah

my A1c moved and I cannot work out whether glucagon is why

Cautionbranch of 4 comments

Genuinely asking, not being difficult. Everyone in c/newbiequestions repeats that dose escalation is important. I believe it, but I have never seen anyone show why, and when I search I get 11 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is…

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4 comments, started 25 days ago
u/baseline_drifteranalytical57 points·25 days ago

the dosing is steep, the constipation reports are real, and nobody knows the human safety yet

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u/titration_marshalmod · c/semaglutide43 points·25 days ago

Small correction: the trial was 10 weeks, not 39. Does not change your point but people will quote it.

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u/isabela_nilsen29 points·25 days ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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u/nabila_bakken20 points·24 days ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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