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c/retatrutide·posted 1 year ago by u/rekha_vestergaard

is it normal to get nausea at week 85

Question Well Actually ×9 Long Haul ×2

Week 20 update. 31kg down from the start, muscle cramps basically gone since about week 60.

Things that worked: consistency, protein at breakfast, walking more than I want to. Things that did not: everything I bought on the internet to help with muscle cramps.

The part that surprised me is how much of this is admin. Ordering, storing, logging, remembering. Nobody mentions that the hard bit is not the drug, it is the routine.

Happy to answer anything. Please do not ask me what dose you should be on.

2,393 up / 714 down77% upvoted56 commentsid 1thzi29 Feb 2025

56 comments

30 in this archive, depth 5

best — the order this archive was captured in

u/jarno_cabrera212 points·1 year ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/rekha_vestergaardOP82 points·1 year ago

TRIUMPH phase 2 showed 97.9% weight loss but the fatigue profile on the highest arm was rough. Phase 2 != phase 3.

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u/customs_seizure_sid175 points·1 year ago

Dose escalation on retatrutide is steeper and faster than on semaglutide. Do not assume the titration patterns transfer.

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u/freya_baptista118 points·1 year ago

Are you quoting phase 2 or is there phase 3 data now?

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u/rekha_vestergaardOP171 points·1 year ago

research use only, handling and analysis, not protocols

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[deleted]111 points·1 year ago

[deleted]

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u/iman_castellanos82 points·1 year ago

What was the dosing schedule in that arm?

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u/rui_only_ro24 points·1 year ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/devils_advocate_d19 points·1 year ago·edited

retatrutide is not approved anywhere for human use, posts must not read as instructions

Adding to this: dose escalation is doing more work than the comment implies.

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u/titration_marshalmod · c/semaglutide14 points·1 year ago

retatrutide is not approved anywhere for human use, posts must not read as instructions Adding to this: dose escalation is doing more work than the co

Adding to this: triple agonist is doing more work than the comment implies.

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u/incretin_ivyMOD64 points·1 year ago

Removed a chain here. The rule is one line long and it is not negotiable.

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u/rekha_vestergaardOP47 points·1 year ago

The glucagon component does different things than dual agonism. The muscle cramps are not just amplified versions.

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u/cagrilintide_enthusiast36 points·1 year ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/nikhil_lindqvist33 points·1 year ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/anya_moreau21 points·1 year ago

the dosing is steep, the injection-site soreness reports are real, and nobody knows the human safety yet

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u/viktor_laurent10 points·1 year ago

This is the "correlation is mechanism" thing again. You changed three variables at once.

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u/nikhil_asante41 points·1 year ago

the dosing is steep, the constipation reports are real, and nobody knows the human safety yet

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u/tired_ledger_notes34 points·1 year ago

the dosing is steep, the constipation reports are real, and nobody knows the human safety yet

Disagree on that part. 98.4% and 98.3% on the same vial is normal.

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u/injection_site_iris31 points·1 year ago·edited

nobody should be giving this to anyone without extensive monitoring

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u/kofi_balogun15 points·1 year ago

Yeah, phase 2 retatrutide is interesting but it is not comparable to phase 3 compounds.

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u/burned_once_twice23 points·1 year ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/incretin_ivypharmacology8 points·1 year ago·edited

Research use material only, no human-use approval anywhere. Posts must describe what happened, not instruct strangers.

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u/trialwatch_theotrial nerd15 points·1 year ago

Crossposting this to c/glp1women because the people who need it are not reading this community.

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u/tired_ledger_notes0 points·1 year ago

nobody should be giving this to anyone without extensive monitoring

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u/naomi_erdogan10 points·1 year ago

Mechanistically the bit that matters is TRIUMPH. It explains most of the early profile and a decent chunk of the outcome.

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u/rohan_cardoso6 points·1 year ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/blunt_coldbox_20243 points·1 year ago

heart rate and dose escalation need actual measurements, not impressions

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u/signe_villalobos1 point·1 year ago

This is correct. Triple agonism is genuinely different.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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c/retatrutide rules
  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
  2. Phase 2 numbers are not maintenance numbers. Cite the trial and the dose arm.
  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
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Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.