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Single comment threadYou are looking at one branch of went too fast on reta and my resting HR told me before i noticed — 25 comments in the full submission. View in context.
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c/retatrutide·submitted 3 days ago by u/bastian_ekstrom

went too fast on reta and my resting HR told me before i noticed

Labbranch of 10 comments

Trying to settle this properly because the thread from last year went in circles. The claim: glucagon matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 21 months without either producing anything. What would actually settle it is 35 people measuring the same…

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10 comments, started 1 days ago
u/solene_ilunga0 points·1 days ago

the glucagon component changes the side effect profile, not just the efficacy

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u/ewan_zielinski1 point·1 days ago

the weight curves are unusually steep, which makes predicting individual response harder

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u/marta_vanhecke-3 points·1 days ago

Did you actually measure heart rate or is that a feeling?

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u/matias_falk1 point·1 days ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/trialwatch_theotrial nerd1 point·20 hr ago

Did you actually measure heart rate or is that a feeling?

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u/honest_syringe_20252 points·15 hr ago

phase 2 numbers are not maintenance numbers, cite the trial

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[removed]1 point·7 hr ago

[removed by moderator]

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u/andres_sorensen1 point·1 days ago

That is net peptide content, not purity. Different number, different meaning.

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u/isabela_nilsen1 point·23 hr ago

the glucagon component changes the side effect profile, not just the efficacy

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u/bastian_ekstromOP1 point·15 hr ago

the glucagon component changes the side effect profile, not just the efficacy

Disagree on that part. 99.2% and 97.6% on the same vial is normal.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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