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c/retatrutide·submitted 2 years ago by u/andres_sorensen

switched from 5mg to 2.5mg and the constipation got better, not worse

Trial Databranch of 7 comments

I have had 24 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 10 days on nominally the same lane, which matters more in summer than in February. The independent number came back 98.4% against a claimed…

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7 comments, started 2 years ago
u/hugo_pires493 points·2 years ago

This is correct. Triple agonism is genuinely different.

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u/ferran_krastev174 points·2 years ago

Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.

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u/nikhil_asante-19 points·2 years ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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u/yara_lindholm1 point·2 years ago

Did you actually measure heart rate or is that a feeling?

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u/nikhil_asante1 point·2 years ago

TRIUMPH data is phase 2, not phase 3, smaller n and shorter

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u/nikhil_lindqvist1 point·2 years ago

the glucagon component changes the side effect profile, not just the efficacy

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u/ferran_krastev1 point·2 years ago

Strongly agree. Heart rate escalation needs the actual data, not impressions.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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