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c/retatrutide·posted 2 years ago by u/iman_castellanos

triple agonist: the version I wish someone had shown me in week 1

Discussion Receipts ×4 Well Actually ×2 Cold Box ×3

Confession thread, sort of.

I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 15 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway.

So now I have muscle cramps I did not need and a data point I cannot interpret. Two lessons in one.

Posting it in the hope that somebody at week 22 reads it before doing the same thing.

8,283 up / 291 down97% upvoted13 commentsid 1art9n20 Dec 2023

13 comments

9 in this archive, depth 4

best — the order this archive was captured in

u/nabila_bakken1.6k points·2 years ago

heart rate and dose escalation need actual measurements, not impressions

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u/arne_amankwah1.1k points·2 years ago

triple agonism is dose escalation, do not generalise

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u/noor_ivaturi258 points·2 years ago·edited

This is correct. Triple agonism is genuinely different.

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u/nikhil_asante302 points·2 years ago

The glucagon component does different things than dual agonism. The early fullness are not just amplified versions.

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u/nadia_trevino91 points·2 years ago

The glucagon component does different things than dual agonism.

Yes, exactly this, and it is the bit that took me 82 weeks to accept.

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u/mod_cold_roommod · c/coldchain62 points·2 years ago

triple agonism plus glucagon is a different physiological state than GIP/GLP-1 dual

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u/blunt_coldbox_202480 points·2 years ago

retatrutide is not approved anywhere for human use, posts must not read as instructions

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u/elodie_grimaldi80 points·2 years ago

heart rate and dose escalation need actual measurements, not impressions

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u/viktor_laurent18 points·2 years ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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About c/retatrutide

Retatrutide: GIP/GLP-1/glucagon triple agonism, the TRIUMPH programme, and the fact that most people discussing it are handling research-grade material with no human-use approval anywhere. Dose-response, heart-rate signal, and the unusually steep phase-2 weight curves get argued about here weekly.

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  1. Retatrutide is not approved anywhere for human use. Posts must not read as usage instructions.
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  3. Heart-rate and dose-escalation reports need actual measurements, not impressions.
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