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c/orforglipron·submitted 5 days ago by u/chidi_yilmaz

[Trial Data] ATTAIN-1 numbers, and why the % is not the headline

Trial Databranch of 4 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking orforglipron against ApoB for 5 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one…

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4 comments, started 3 days ago
u/marit_laurent22 points·3 days ago

Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.

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u/erez_yilmaz17 points·3 days ago·edited

small molecule, not a peptide, purity discussion is different

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u/certified_referenceQC8 points·2 days ago

the nausea profile is speculative at this stage

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u/kenji_laurent2 points·2 days ago

Second this question. I have wondered about non-peptide for 16 months and never seen a straight answer.

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The small-molecule oral: why a non-peptide agonist escapes the absorption problems of oral semaglutide, what the ATTAIN and ACHIEVE readouts showed, and what a pill with no refrigeration requirement would do to the entire supply conversation this site is built around.

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