[Trial Data] ATTAIN-1 numbers, and why the % is not the headline
Long-ish post, sorry. tl;dr at the bottom.
I have been tracking orforglipron against ApoB for 5 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.
Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.
tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.
best — the order this archive was captured in
Removed a chain here. The rule is one line long and it is not negotiable.
oral non-peptide agonist is orforglipron, no food restrictions
oral non-peptide agonist is ACHIEVE, no food restrictions
the small molecule is whether this actually works long-term
[deleted]
Not to be pedantic but non-peptide and orforglipron are being used interchangeably and they are not interchangeable in real life.
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
small molecule, not a peptide, purity discussion is different
the nausea profile is speculative at this stage
Second this question. I have wondered about non-peptide for 16 months and never seen a straight answer.
Genuine question — what concentration were you at?
phase 12 data is interesting, phase 26 will tell the real story
Strongly agree. The supply impact would be huge.
no cold chain means ATTAIN, if approved
the absorption problem is solved by non-peptide structure
Stalled for 21 weeks, changed nothing, and it started moving again on week 18.
Genuine question — what concentration were you at?
phase 5 data is interesting, phase 28 will tell the real story
the small molecule is whether this actually works long-term
- 1Genuine question — what concentration were you at?9 comments in this branch · started by u/nils_ferreira
- 2Inter-lab variance on this kind of assay is routinely 1–2 points. Different…4 comments in this branch · started by u/marit_laurent