[Discussion] the ACHIEVE advice in here is 11 years out of date
Posting this because I searched for it and got nothing useful. Setup: 15mg, week 60, constipation present but not ruining anything. I changed exactly one variable — ATTAIN — and tracked it for 14 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am…
Retitled to remove editorialising. Put the evidence in the body.
The confident tone is doing a lot of work that the evidence is not.
the nausea profile is speculative at this stage
Not to be pedantic but oral GLP-1 and small molecule are being used interchangeably and they are not interchangeable in real life.
Not to be pedantic but oral GLP-1 and small molecule are being used interchangeably and they are not interchangeable in real life.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
the reflux profile is speculative at this stage
the absorption problem is solved by non-peptide structure