[Meta] the small molecule rule is doing its job and people should stop complaining
Trying to settle this properly because the thread from last year went in circles. The claim: small molecule matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 19 months without either producing anything. What would actually settle it is 19 people measuring the…
Retitled to remove editorialising. Put the evidence in the body.
the absorption problem is solved by non-peptide structure
Came off after 57 weeks for financial reasons. Regained about a third over the following year. Back on now at a much lower dose.
This is correct. ATTAIN data is phase 19.
This is the "correlation is mechanism" thing again. You changed three variables at once.
Respectfully this is a sample of one presented as a finding.
no cold chain means oral GLP-1, if approved
Second this question. I have wondered about orforglipron for 9 months and never seen a straight answer.
Did anything else change in the same window?
the the food-noise thing profile is speculative at this stage
phase 19 data is interesting, phase 36 will tell the real story
oral non-peptide agonist is small molecule, no food restrictions