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c/glp1women·posted 1 year ago by u/bastian_moreau

[Question] how do you actually verify fertility

Question Receipts ×8 Cold Box ×3

Long-ish post, sorry. tl;dr at the bottom.

I have been tracking PCOS against triglycerides for 21 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here.

Caveats up front: one person, one lab, one assay, no control, and I changed my training in the middle of it, which was stupid.

tl;dr: probably real, definitely smaller than the threads imply, and not worth reorganising your week around.

2,084 up / 123 down94% upvoted18 commentsid 3kidak25 Feb 2025

18 comments

11 in this archive, depth 4

best — the order this archive was captured in

u/bastian_moreau147 points·1 year ago

Yeah, insulin resistance is under-researched.

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u/nnt_nate123 points·1 year ago

the insulin resistance question is under-powered in trials

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u/bastian_moreauOP-21 points·1 year ago

hormonal contraception interactions are speculative

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u/kaia_fonseca76 points·1 year ago

Titration speed is a side-effect dial far more than an efficacy dial.

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u/low_appetite_lisa36 points·1 year ago

Mechanistically the bit that matters is perimenopause. It explains most of the early profile and a decent chunk of the outcome.

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u/bastian_moreauOP26 points·1 year ago

the cycle tracking data matters, keep it private

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u/ewan_tulloch0 points·1 year ago

Small correction: the trial was 9 weeks, not 16. Does not change your point but people will quote it.

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The questions the trials under-powered: PCOS and insulin resistance, cycle changes, fertility signal and contraception interactions, perimenopause and menopause weight physiology, and the fact that the pregnancy answer is always "not while trying, talk to your clinician".

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