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c/glp1science·submitted 2 months ago by u/osman_eriksen

pharmacology is the most under-discussed thing in c/glp1women

Explainerbranch of 7 comments

Confession thread, sort of. I went from 1.0mg to 15mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 3 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have constipation…

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7 comments, started 2 months ago
u/split_dose_sceptic16 points·2 months ago

Rodent, human, or in vitro?

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u/enzo_petrescu7 points·2 months ago

central appetite signalling is real but people overweight it

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u/vikram_mbeki2 points·2 months ago

receptor distribution matters, GLP-1 is not everywhere

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u/lina_ndiaye12 points·2 months ago

Strongly agree. Central appetite is real but people overstate it.

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u/georgi_chowdhury3 points·2 months ago

cite the paper: journal, year, first author, links optional

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u/nadia_bakker1 point·2 months ago

This is correct. Rodent data is investigational, not predictive.

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[deleted]1 point·2 months ago

[deleted]

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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