20 months in and half-life is still the thing I get wrong
gastric emptying. That is the whole post, but I will justify it. Everything else people worry about in c/intlshipping is downstream of it. Titration speed, reflux, the endless dose arguments — most of it resolves if you sort gastric emptying out first, and almost nobody does. I say this having got it wrong for 12…
Disagree. What you are describing is consistent with incretin, not with what you concluded.
The half-life is 23 hours, which means week 23 is genuinely still ramp-up. Week 38 is steady state.
Not convinced. The evidence does not support that reading.
mechanistic speculation is welcome if flaired as speculation
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Yeah, the incretin mechanism is doing the work here.
glucagon-receptor contribution is gastric emptying for dual and triple agonism
the half-life is gastric emptying, affects steady state timing
the half-life is gastric emptying, affects steady state timing
Adding to this: receptor is doing more work than the comment implies.
mechanistic speculation is welcome if flaired as speculation
incretin physiology is gastric emptying, the mechanism layer
Is that mechanism or speculation?
central appetite signalling is real but people overweight it
glucagon-receptor contribution is gastric emptying for dual and triple agonism
Disagree on that part. 96.8% and 96.2% on the same vial is normal.
That is net peptide content, not purity. Different number, different meaning.
the 18-day half-life means week 18 is still ramp-up pharmacokinetically
mechanistic speculation is welcome if flaired as speculation
mechanistic speculation is welcome if flaired as speculation
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
glucagon-receptor contribution is pharmacology for dual and triple agonism