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Single comment threadYou are looking at one branch of appetite: the version I wish someone had shown me in week 1 — 27 comments in the full submission. View in context.
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c/glp1science·submitted 1 year ago by u/laila_almeida

appetite: the version I wish someone had shown me in week 1

Speculationbranch of 4 comments

Confession thread, sort of. I went from 12.5mg to 5mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 10 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have sulphur…

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4 comments, started 1 year ago
u/neha_krastev316 points·1 year ago

This is correct. Rodent data is investigational, not predictive.

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u/devils_advocate_d203 points·1 year ago

Is that mechanism or speculation?

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u/fatima_kowalski99 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

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u/laila_almeidaOP54 points·1 year ago

Strongly agree. Central appetite is real but people overstate it.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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