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c/glp1science·submitted 1 year ago by u/gustav_vermeulen

does mechanism actually matter or is it forum lore at this point

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Posting this because I searched for it and got nothing useful. Setup: 12.5mg, week 36, constipation present but not ruining anything. I changed exactly one variable — receptor — and tracked it for 19 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I…

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4 comments, started 1 year ago
u/employer_carveout36 points·1 year ago

Is that mechanism or speculation?

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u/marisol_kravchenko10 points·1 year ago

gastric emptying is real and explains most early reflux

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u/employer_carveout3 points·1 year ago

do not extrapolate rodent data to human dosing without saying so

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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