help me understand incretin, I have read the wiki twice
Trying to settle this properly because the thread from last year went in circles.
The claim: mechanism matters. The counter-claim: it is measurement error. Both sides have been asserting it confidently for about 13 months without either producing anything.
What would actually settle it is 11 people measuring the same thing the same way. I have started; my numbers are below. They lean one way but not strongly enough for me to declare victory.
If you have data, post the data. If you have an opinion, flair it as an opinion.
best — the order this archive was captured in
The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.
Stomach physiology changed when I moved up to 2.4mg. Gastric emptying lag is the whole story.
do not extrapolate rodent data to human dosing without saying so
The confident tone is doing a lot of work that the evidence is not.
rodent appetite tells you what to investigate, not what to expect in humans
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Where does the appetite data actually come from?
I love that this community will spend 40 comments on a detail. That pedantry is why the numbers here matter.
Strongly agree. Central appetite is real but people overstate it.
the half-life is incretin, affects steady state timing
Strongly agree. Central appetite is real but people overstate it.
Strongly agree.
Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.
glucagon-receptor contribution is mechanism for dual and triple agonism
rodent gastric emptying tells you what to investigate, not what to expect in humans
rodent pharmacology tells you what to investigate, not what to expect in humans
do not extrapolate rodent data to human dosing without saying so
This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.
do not extrapolate rodent data to human dosing without saying so
Where does the receptor data actually come from?
The half-life is 18 hours, which means week 18 is genuinely still ramp-up. Week 7 is steady state.
- 1The practical rule people converge on is 28 days at fridge temperature after…7 comments in this branch · started by u/gustav_vermeulen
- 2Strongly agree. Central appetite is real but people overstate it.5 comments in this branch · started by u/hassan_ostergaard