[Results] 87 weeks, 25kg, and receptor was the hard part
I have had 17 orders now and I keep a table, so here is the honest summary rather than a vibe. Material has been consistent. Communication has not. Shipping has varied by about 32 days on nominally the same lane, which matters more in summer than in February. The independent number came back 98.4% against a claimed…
Mechanistically the bit that matters is appetite. It explains most of the early profile and a decent chunk of the outcome.
The pharmacology literature is interesting but rodent models do not scale linearly to human dosing.
the half-life is half-life, affects steady state timing
This is correct. Rodent data is investigational, not predictive.
do not extrapolate rodent data to human dosing without saying so
Strongly agree. Central appetite is real but people overstate it.
Retitled to remove editorialising. Put the evidence in the body.
the 12-day half-life means week 12 is still ramp-up pharmacokinetically