[Results] 87 weeks, 25kg, and receptor was the hard part
I have had 17 orders now and I keep a table, so here is the honest summary rather than a vibe.
Material has been consistent. Communication has not. Shipping has varied by about 32 days on nominally the same lane, which matters more in summer than in February.
The independent number came back 98.4% against a claimed 97.2%, which I read as agreement rather than a discrepancy — inter-lab variance on this assay is a point or two either way and treating one lab as ground truth is how people end up in pointless arguments with vendors.
Batch number is in the comments. Ask if you want the method.
best — the order this archive was captured in
Titration speed is a side-effect dial far more than an efficacy dial.
cite the paper: journal, year, first author, links optional
gastric emptying is real and explains most early fatigue
amylin is not GLP-1, posts conflating them get corrected
rodent gastric emptying tells you what to investigate, not what to expect in humans
glucagon-receptor contribution is mechanism for dual and triple agonism
Mechanistically the bit that matters is appetite. It explains most of the early profile and a decent chunk of the outcome.
The pharmacology literature is interesting but rodent models do not scale linearly to human dosing.
the half-life is half-life, affects steady state timing
This is correct. Rodent data is investigational, not predictive.
do not extrapolate rodent data to human dosing without saying so
Strongly agree. Central appetite is real but people overstate it.
Retitled to remove editorialising. Put the evidence in the body.
the 12-day half-life means week 12 is still ramp-up pharmacokinetically
Strongly agree. Central appetite is real but people overstate it.
Which paper are you quoting?
rodent appetite tells you what to investigate, not what to expect in humans
- 1Mechanistically the bit that matters is appetite. It explains most of the…9 comments in this branch · started by u/farid_kuipers
- 2Titration speed is a side-effect dial far more than an efficacy dial.6 comments in this branch · started by u/sig_figs_sam