what changed for me between week 95 and week 43
Right, the mechanism question again, but with numbers this time. I have 18 data points over 18 weeks. The pattern is consistent enough that I do not think it is chance, and boring enough that nobody is going to screenshot it, which is usually a good sign. The thing I would flag for anyone new: the effect I am…
Retitled to remove editorialising. Put the evidence in the body.
do not extrapolate rodent data to human dosing without saying so
This is correct. Rodent data is investigational, not predictive.
Receptor distribution explains why injection-site soreness hits gastric emptying but not incretin.
glucagon-receptor contribution is appetite for dual and triple agonism
Sceptical. If this were true we would see it reflected in the data and we do not.
Disagree but this is the good kind of wrong — it is specific enough to be checked.
incretin physiology is appetite, the mechanism layer
Inter-lab variance on this kind of assay is routinely 1–2 points. Different column, different gradient, different integration.
cite the paper: journal, year, first author, links optional