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c/glp1science·submitted 1 year ago by u/bastian_ekstrom

unpopular opinion: mechanism is massively overrated

Needs Sourcebranch of 6 comments

Posting this because I searched for it and got nothing useful. Setup: 0.25mg, week 43, sulphur burps present but not ruining anything. I changed exactly one variable — pharmacology — and tracked it for 13 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it.…

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6 comments, started 1 year ago
u/tomas_broberg28 points·1 year ago

This is correct. Rodent data is investigational, not predictive.

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u/analog_alphabet19 points·1 year ago

Where does the incretin data actually come from?

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u/lina_ndiaye34 points·1 year ago

This is correct.

Adding to this: mechanism is doing more work than the comment implies.

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u/karma_irrelevant9 points·1 year ago

glucagon-receptor contribution is gastric emptying for dual and triple agonism

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u/sig_figs_sammod · analytical8 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

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u/devils_advocate_d18 points·1 year ago

Edit to your parent would help — the concentration you quoted assumes one scenario and you have written another above it.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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