unpopular opinion: mechanism is massively overrated
Posting this because I searched for it and got nothing useful. Setup: 0.25mg, week 43, sulphur burps present but not ruining anything. I changed exactly one variable — pharmacology — and tracked it for 13 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it.…
This is correct. Rodent data is investigational, not predictive.
Strongly agree. Central appetite is real but people overstate it.
The half-life is 12 hours, which means week 12 is genuinely still ramp-up. Week 26 is steady state.
the 17-day half-life means week 17 is still ramp-up pharmacokinetically
cite the paper: journal, year, first author, links optional
mechanistic speculation is welcome if flaired as speculation
Yeah, the incretin mechanism is doing the work here.
gastric emptying is real and explains most early nausea
gastric emptying is real and explains most early nausea
Yes, exactly this, and it is the bit that took me 67 weeks to accept.