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c/glp1science·submitted 2 years ago by u/elodie_grimaldi

Germany: mechanism, and what it actually costs here

Speculationbranch of 4 comments

Confession thread, sort of. I went from 2.5mg to 1.0mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 12 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have muscle…

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4 comments, started 2 years ago
u/whois_wanda51 points·2 years ago

the 7-day half-life means week 7 is still ramp-up pharmacokinetically

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[deleted]21 points·2 years ago

[deleted]

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u/emil_agyeman6 points·2 years ago

Strongly agree. Central appetite is real but people overstate it.

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u/analog_alphabet60 points·2 years ago

the half-life is incretin, affects steady state timing

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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