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c/glp1science·submitted 2 years ago by u/camila_mensa

pharmacology — my 21-week log, condensed into one table

Questionbranch of 4 comments

Genuinely asking, not being difficult. Everyone in c/tapering repeats that incretin is important. I believe it, but I have never seen anyone show why, and when I search I get 8 threads of people agreeing with each other. Is there a paper? Is there a measurement? Or is this one of those things that is true because it…

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4 comments, started 2 years ago
u/viktor_girard4 points·2 years ago

Where does the appetite data actually come from?

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u/dose_creep_dan3 points·2 years ago

Yeah, the incretin mechanism is doing the work here.

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u/formulary_fighterappeals1 point·2 years ago

mechanistic speculation is welcome if flaired as speculation

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u/analog_alphabet1 point·2 years ago

mechanistic speculation is welcome if flaired as speculation

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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