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c/glp1science·posted 2 years ago by u/camila_mensa

pharmacology — my 21-week log, condensed into one table

Question

Genuinely asking, not being difficult.

Everyone in c/tapering repeats that incretin is important. I believe it, but I have never seen anyone show why, and when I search I get 8 threads of people agreeing with each other.

Is there a paper? Is there a measurement? Or is this one of those things that is true because it has been repeated since 2023?

I am not trying to be the "source?" guy. I would just like a source.

0 up / 0 down47% upvoted4 commentsid 1yjhmu6 Dec 2023

4 comments

4 in this archive, depth 4

best — the order this archive was captured in

u/viktor_girard4 points·2 years ago

Where does the appetite data actually come from?

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u/dose_creep_dan3 points·2 years ago

Yeah, the incretin mechanism is doing the work here.

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u/formulary_fighterappeals1 point·2 years ago

mechanistic speculation is welcome if flaired as speculation

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u/analog_alphabet1 point·2 years ago

mechanistic speculation is welcome if flaired as speculation

Counter-anecdote: opposite result, same dose. Which mostly tells us the variance is huge.

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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