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c/glp1science·submitted 1 year ago by u/hassan_castellanos

[Discussion] half-life is doing more work than we give it credit for

Discussionbranch of 4 comments

Confession thread, sort of. I went from 0.25mg to 10mg much faster than I should have because the scale had stalled and I got impatient. The stall broke about 13 weeks later, at which point I had no way of knowing whether the dose increase did anything or whether it would have broken anyway. So now I have reflux I…

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4 comments, started 1 year ago
u/laila_almeida340 points·1 year ago

Stomach physiology changed when I moved up to 7.5mg. Gastric emptying lag is the whole story.

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u/ferran_dahlberg107 points·1 year ago

Rodent, human, or in vitro?

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u/hassan_castellanosOP-23 points·1 year ago

glucagon-receptor contribution is pharmacology for dual and triple agonism

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u/split_dose_sceptic1 point·1 year ago

receptor distribution matters, GLP-1 is not everywhere

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