GLPHubglpresearchhub.com
Read-only archive. GLP Research Hub is a static community record — nothing here is for sale, no account is needed, and no vote you cast is counted. Why?
Single comment threadYou are looking at one branch of genuine question about receptor that I am slightly embarrassed to ask — 27 comments in the full submission. View in context.
3.6k
c/glp1science·submitted 2 years ago by u/maintenance_mode_max

genuine question about receptor that I am slightly embarrassed to ask

Needs Sourcebranch of 8 comments

Posting this because I searched for it and got nothing useful. Setup: 10mg, week 27, constipation present but not ruining anything. I changed exactly one variable — receptor — and tracked it for 10 weeks. Result: a difference, but a small one, and well inside what I would call noise if someone else posted it. So I am…

Read the full submission and all 27 comments →

This branch

8 comments, started 2 years ago
u/bastian_eriksen75 points·2 years ago

Is that mechanism or speculation?

replysharereportpermalink
u/ismael_eriksen48 points·2 years ago·edited

amylin is not GLP-1, posts conflating them get corrected

replysharereportpermalink
u/noor_hovland38 points·2 years ago·edited

amylin is not GLP-1, posts conflating them get corrected

Adding to this: half-life is doing more work than the comment implies.

replysharereportpermalink
u/gustav_vermeulen21 points·2 years ago·edited

receptor distribution matters, GLP-1 is not everywhere

replysharereportpermalink
u/nora_lundgren61 points·2 years ago

Slight fix: the number was 99.1, not 99.0. Decimal point, but a fairly consequential one.

replysharereportpermalink
u/maintenance_mode_maxOPmaintenance37 points·2 years ago

glucagon-receptor contribution is incretin for dual and triple agonism

replysharereportpermalink
load more comments (2) →

← back to the whole thread

About c/glp1science

The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

50kmembers
95submissions
Oct 2023created
submissions / month, last year
Sponsored

Janoshik Analytical

Independent HPLC and mass spec. The number you get is the number they found.

janoshik.comSponsored

GL Biochem (Shanghai)

Custom peptides and amino acids direct from the manufacturer since 1998. ISO 9001 / cGMP. Batch COA every order.

glbiochem.net
More in c/glp1science
c/glp1science rules
  1. Cite the paper: journal, year, first author. Links optional, citation mandatory.
  2. Mechanistic speculation is welcome if flaired as speculation.
  3. No extrapolating rodent data to human dosing without saying that is what you are doing.
  4. Independent community. Nobody here sells anything, and anyone who tries is banned.
  5. Not medical advice. Describe what you did; never prescribe to a stranger.
  6. Claims need evidence. Batch numbers, dated screenshots, independent test reports, or a citation.
  7. No referral links, discount codes or affiliate URLs. Permanent ban, no appeal.
  8. No contact handles, wallet addresses or tracking numbers — they identify people.
  9. Be recognisably decent. Disagree hard, insult nobody.
Full rules and how they are enforced →
Moderators
u/incretin_ivyu/trialwatch_theou/gastric_emptying_gu/sig_figs_sam
Volunteers. Unpaid, unaffiliated, and reachable through modmail only.
Before you read on

Several compounds discussed on GLP Research Hub are sold for research use only and are not approved for human use anywhere. Nothing here is medical advice and none of it is written by your clinician. If a post reads like an instruction, treat it as a description of what one stranger did.

Full disclaimer →