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c/glp1science·submitted 1 year ago by u/annika_fonseca

[Results] 32 weeks, 31kg, and pharmacology was the hard part

Questionbranch of 6 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking mechanism against triglycerides for 25 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab,…

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6 comments, started 1 year ago
u/analog_alphabet30 points·1 year ago

Strongly agree. Central appetite is real but people overstate it.

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u/annika_fonsecaOP22 points·1 year ago

Rodent, human, or in vitro?

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u/employer_carveout35 points·1 year ago

No. This is the kind of confident post that gets copied into a screenshot and repeated for years. Where is the evidence.

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u/priya_guerrero28 points·1 year ago

amylin is not GLP-1, posts conflating them get corrected

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u/runa_cabrera17 points·1 year ago

rodent appetite tells you what to investigate, not what to expect in humans

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u/flair_enthusiast25 points·1 year ago

glucagon-receptor contribution is incretin for dual and triple agonism

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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