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c/glp1science·submitted 1 months ago by u/lurker_for_years

someone explain receptor to me like I have not read a paper in years

Questionbranch of 5 comments

Long-ish post, sorry. tl;dr at the bottom. I have been tracking mechanism against triglycerides for 7 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab,…

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5 comments, started 1 months ago
u/neha_krastev49 points·1 months ago

Which paper are you quoting?

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u/incretin_ivypharmacology20 points·1 months ago

the half-life is appetite, affects steady state timing

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u/ireland_drugs_pay31 points·1 months ago

do not extrapolate rodent data to human dosing without saying so

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u/flair_enthusiast23 points·1 months ago

This is correct. Rodent data is investigational, not predictive.

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[removed]15 points·1 months ago

[removed by moderator]

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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