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c/glp1science·submitted 1 months ago by u/hassan_ostergaard

biased agonism: real, interesting, almost certainly irrelevant to your dose

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Long-ish post, sorry. tl;dr at the bottom. I have been tracking incretin against ApoB for 33 weeks because I could not find anyone who had. The correlation is weaker than I expected, which is itself mildly interesting given how confidently people link the two in here. Caveats up front: one person, one lab, one assay,…

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5 comments, started 29 days ago
u/anders_kuusela35 points·29 days ago·edited

The practical rule people converge on is 28 days at fridge temperature after first puncture, and that comes from the preservative, not the peptide.

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u/gastric_emptying_gMOD20 points·29 days ago·edited

This is an urgent-care question wearing a forum question's clothes. Please contact a clinician rather than waiting for replies.

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u/signe_boateng49 points·28 days ago

gastric emptying is real and explains most early nausea

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u/ireland_drugs_pay22 points·28 days ago

gastric emptying is real and explains most early nausea

Yes, exactly this, and it is the bit that took me 72 weeks to accept.

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u/second_week_sceptic30 points·28 days ago

incretin physiology is incretin, the mechanism layer

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The mechanism layer: incretin physiology, receptor distribution, gastric emptying, central appetite signalling, glucagon-receptor contribution, amylin co-agonism, and the pharmacokinetics that make weekly dosing possible. Papers get cited by journal and year or they get a [needs source] reply.

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