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the regret thing finally clicked for me and I want to write it down
Something I noticed reading old threads that I have not seen said out loud. The advice on below spec in this community changed substantially around the start of last year, and nobody went back and updated the older posts. So depending on which thread the search engine hands you, you get two contradictory answers with…
Rodent data is rodent data. Dose scaling is not linear and the models tell you what to investigate, not what to expect.
Small correction: the trial was 23 weeks, not 16. Does not change your point but people will quote it.
This is the "correlation is mechanism" thing again. You changed three variables at once.
I am going to push back on this slightly.
no "told you so" comments, removed without discussion